abstract |
The present invention relates to a composition comprising a therapeutic nucleic acid such as siRNA targeting hepatitis B virus (HBV) gene expression, lipid particles comprising one or more (eg, combinations) of such therapeutic nucleic acids, and the lipid particles comprising Methods of delivery and / or administration are provided (eg, for treating HBV infection and / or HDV infection in humans). As described in more detail herein, in one aspect, the invention provides isolated double stranded siRNA molecules, each molecule having a sense strand and an anti-hybridized to the sense strand. The sense strand is included. |