| abstract |
The present invention includes an extracellular domain including an antigen binding domain, a transmembrane domain, and an intracellular domain, wherein the intracellular domain includes an immunoreceptor tyrosine-based switch motif ITSM, An inhibitory chimeric antigen receptor having the amino acid sequence TX 1 YX 2 X 3 X 4 , X 1 is an amino acid, X 2 is an amino acid, X 3 is an amino acid, and X 4 is V or I ( N-CAR). [Figure 1] |