| abstract |
The present invention relates to novel substituted bridged urea analog compounds of formula (I) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, methods of preparation, and cellular, alone or in combination with other therapeutic agents. As a sirtuin modulator useful for increasing lifespan and for example, but not limited to, aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular diseases, blood coagulation disorders, inflammation, cancer and It relates to the use of said compounds in treating and / or preventing various diseases and disorders, including diseases or disorders that would benefit from flushing and / or increased mitochondrial activity. |