http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017534655-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-04 |
| filingDate | 2015-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2017534655-A |
| titleOfInvention | Purification method of Axl tyrosine receptor kinase inhibitor “R428” |
| abstract | 1- (6,7-dihydro -5H- benzo [6,7] cyclohepta [1, 2-c] pyridazin-3-yl) -N 3 - (7- (pyrrolidin-1-yl) -6,7, A method for purifying 8,9-tetrahydro-5H-benzo [7] annulen-2-yl) -1H-1,2,4-triazole-3,5-diamine free base is described, the method comprising: the comprising: a) a quantity of crude 1- (6,7-dihydro -5H- benzo [6,7] cyclohepta [1, 2-c] pyridazin-3-yl) -N 3 - (7- ( Pyrrolidin-1-yl) -6,7,8,9-tetrahydro-5H-benzo [7] annulen-2-yl) -1H-1,2,4-triazole-3,5-diamine together with acid C 1-5 were dissolved in a mixed solvent of alcohol and water, and, ) (The pH of the resulting solution from a), 1-(6,7-dihydro -5H- benzo [6,7] cyclohepta [1, 2-c] pyridazin-3-yl) -N 3 - (7- (Pyrrolidin-1-yl) -6,7,8,9-tetrahydro-5H-benzo [7] annulen-2-yl) -1H-1,2,4-triazole-3,5-diamine free base is an alcohol -Increase from water mixture until precipitation. |
| priorityDate | 2014-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.