| abstract |
Disclosed are compounds having cytotoxic and / or anti-mitotic activity. Also disclosed are methods related to the preparation and use of such compounds, and pharmaceutical compositions comprising such compounds. It has the structure: (T)-(L)-(D), (T) is the target moiety, (L) is an optional linker, and (D) is cytotoxic and / or anti-threaded. Also disclosed are compositions that are compounds having mitotic activity. [Selection figure] None |