| abstract |
A dry powder comprising dry particles comprising a tiotropium salt, one or more amino acids, and an acid content, and optionally sodium chloride, and / or one or more other therapeutic agents A dry powder wherein the molar ratio of to amino acids is about 0.0005 to about 5, or about 0.002 to about 1. In one aspect, a dry powder comprising dry particles is suitable for respiratory administration. In one aspect, the dry powder comprising dry particles comprises tiotropium salt, one or more amino acids, acid content, sodium chloride, and optionally one or more other therapeutic agents. Wherein tiotropium salt is about 0.01% to about 0.5%, leucine is about 5% to about 40%, and sodium chloride is about 50% to about 90%. Wherein the optional one or more other therapeutic agents is up to about 30% and the acid to amino acid molar ratio is from 0.002 to about 1, where all percentages are on an anhydrous basis. The total percentage of all components of the respirable dry particles reaches 100%. |