abstract |
Formula (I): (Wherein R 1 , R 2a , R 2b , R 3 and ring B are as defined herein, and ring A is represented by formula (A-i), (A-ii), or ( A-iii): Wherein R, R, R, R, and R are as defined herein, and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof Provided in the certificate. The compounds of the present invention are useful for inhibiting CARM1 activity. Also described are methods of using this compound to treat CARM1-mediated diseases. |