| abstract |
The present invention provides an antibody or antigen-binding fragment thereof having binding specificity for human interleukin 1 receptor accessory protein (IL1RAP), wherein the antibody or antigen-binding fragment is capable of inhibiting against domain 3 of human IL1RAP. is there. The invention further provides the use of such antibodies or antigen-binding fragments in the treatment and / or diagnosis of cancers such as leukemia and melanoma. [Selection] Figure 7 (C) |