| abstract |
The present invention relates to a method for monitoring cathepsin S inhibitor activity in an animal tissue sample, the method comprising (a) preparing an animal tissue sample to which a cathepsin S inhibitor has been administered or in vitro. Preparing a tissue sample of an animal contacted with a cathepsin S inhibitor in step, wherein the tissue sample contains leukocytes, (b) the level of li p10 peptide in leukocytes of the tissue sample in step (a), Measuring by flow cytometry, and (c) associating li p10 peptide levels in leukocytes with cathepsin S inhibitor dose, wherein the cathepsin S inhibitor results in increased levels of li p10 peptides in leukocytes. Including. |