| abstract |
The present disclosure provides formula (I): [Chemical 1] Wherein R 1 , B, X, and Z are defined as described herein, and pharmaceutically acceptable salts and solvates thereof are provided. . The disclosure also relates to the use of compounds of formula I for treating diseases responsive to blockade of SMYD proteins such as SMYD3 or SMYD2. The compounds of the present disclosure are particularly useful for treating cancer. |