| abstract |
Disclosed is a chemical moiety that is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein Y, R a , R a ′, R b , R c , X 1 , X 2 , X 3 , R d , Z 1 , and Z 2 have the values described herein, and the stereochemical configuration shown at the asterisked positions indicates absolute stereochemistry). Chemical components according to the present disclosure may be useful as inhibitors of Sumo activating enzyme (SAE). Further provided are pharmaceutical compositions comprising the compounds of the present disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular, and neurodegenerative diseases or disorders. [Selection] Figure 1 |