| abstract |
The present invention provides a benzimidazole derivative having the general formula I wherein n is 0 or 1, X 1 and X 2 are independently CR 5 or N, Y is alkylene, R 1 is hydrogen, Halogen, alkoxy, —NH 2 , —NHR 6 , —NR 7 R 8 or —NH— (R 9 ) n —R 10 , n is 0 or 1, and R 2 is hydrogen, halogen, alkyl, —NH 2 , —NHR 6 , —NR 7 R 8 or —NH— (R 9 ) n —R 10 , wherein R 3 is hydrogen optionally substituted independently with 1 to 4 R a groups. , Hydroxyl, OR 11 , —NR 7 R 8 , alkoxy, alkyl, cycloalkyl, haloalkyl, —C (O) NHR 11 , aryl, heteroaryl or heterocyclyl, wherein R 4 is —NH 2 , —N (R 12 (V) p R 13, -NH (V) p -OR 14, -NHC (O) R 15, or a group of formula 1a), and their use in the treatment of disease. |