| abstract |
The present invention relates to a fusion protein composed of the extracellular domain of PD-L1 and a modified immunoglobulin Fc region. The extracellular domain of PD-L1 and fragments thereof have excellent immunomodulatory activity and can be used as immunomodulators when a modified immunoglobulin Fc region is coupled thereto. Therefore, the PD-L1 fusion protein according to the present invention shows its excellent effect in disease models of inflammatory bowel disease, colitis, psoriasis, asthma and arthritis and is therefore used very effectively for the treatment of such diseases Can be done. |