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filingDate 2015-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2017-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2017518340-A
titleOfInvention Methods of treating and preventing vascular instability diseases
abstract Disclosed are methods of treating and preventing vascular instability diseases such as cerebral cavernous vascular malformations by administration of tempol, cholecalciferol, derivatives thereof, pharmaceutically acceptable salts thereof, or combinations thereof. Disclosed is a method for reducing the number of CCM lesions in a patient having or at risk of developing at least one cerebral cavernous malformation (CCM) lesion. Disclosed are methods for reducing the growth rate of the number of CCM lesions in a patient having or at risk of developing at least one cerebral cavernous malformation (CCM) lesion. Disclosed are methods for preventing or treating signs or symptoms of CCM lesions in patients with at least one cerebral cavernous vascular malformation (CCM). Disclosed are methods of reducing cerebrovascular inflammation, reducing cerebrovascular permeability, or both in patients having or at risk of developing cerebrospinal vascular malformation (CCM) lesions.
priorityDate 2014-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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