| abstract |
Complexes of polynucleotides such as p97 (melanotransferrin) and small interfering RNA (siRNA) molecules, and compositions and methods related to their use, eg, polynucleotides such as siRNA molecules that cross the blood brain barrier (BBB) And / or improve their tissue penetration in the CNS and / or peripheral tissues, thereby treating and / or diagnosing various diseases, including those with central nervous system (CNS) components A method is provided. [Selection] Figure 10 |