abstract |
The present invention provides quinazoline and quinoline compounds, compositions thereof, and methods of using them. The activity of such compounds as inhibitors of IRAK enzymes is also disclosed. The present invention relates to compounds and methods useful for inhibiting one or more interleukin-1 receptor-related kinases (“IRAKs”). The present invention also provides pharmaceutically acceptable compositions containing the compounds of the present invention and methods of using these compositions in the treatment of various disorders. |