| abstract |
As demonstrated herein, soluble human FcRn binds to AFP with higher affinity than observed with albumin and can interfere with FcRn-mediated protection of IgG and functional association with IgG. . Accordingly, provided herein are, in some aspects, compositions and methods for inhibiting the interaction of FcRn and AFP in diseases or disorders where elevated AFP levels are associated with immunosuppression. It is. Also provided herein, in some aspects, are FcRn and AFP in a disease or disorder associated with a decrease in AFP levels or in a disease or disorder in which increased AFP levels increase with immunosuppression. Compositions and methods for enhancing or enhancing interactions. |