| abstract |
The present invention relates to the field of pharmacology. In particular, the present invention relates to novel analogs of apelin and their therapeutic uses. Including a lanthionine bridge of structure Ala-S-Ala or a methyllanthionine bridge of structure Abu-S-Ala or Ala-S-Abu, wherein the (methyl) lanthionine bridge is i, i + 3; i, i + 4, i, i + 5, or Cyclic apelin analogs of the general formula X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14, which are i, i + 6 in size, are provided. [Selection figure] None |