| abstract |
In the present invention, an anti-death receptor 3 (DR3) antagonist IgG antibody and the antibody fragment are provided, and the antibody and the antibody fragment show a decreased agonist activity or no agonist activity against DR3 due to their binding. Antibody compositions and antibody fragment compositions comprising these antibodies or the antibody fragments, nucleotide sequences encoding the antibodies or the antibody fragments, vectors comprising the nucleotide sequences, antibodies or amino acid sequences of the antibody fragments, antibodies or the antibody fragments Methods of producing are provided, as well as methods of reducing the agonistic potency of antibodies to DR3 due to their binding. |