| abstract |
The present invention relates to substituted 2-pyridones and pyrazinones of formula (1), their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing them, and to the lung, gastrointestinal and urogenital It relates to methods of using it as a medicament for treating and / or preventing diseases, skin and eye inflammatory diseases, and other autoimmune and allergic disorders, allograft rejection, and neoplastic diseases. |