abstract |
The present invention relates to a compound of any one of formulas (I) to (V) (for example, a compound of any one of formulas (I-1) to (I-9)) and a Waldenstream using the compound. Methods are provided for treating macroglobulinemia (WM) and other B cell neoplasms, comprising administering an effective amount of a compound to a subject in need thereof. The compounds include breton tyrosine kinase (BTK), interleukin-1 receptor-related kinase 1 (IRAK1), interleukin-1 receptor-related kinase 4 (IRAK4), bone marrow kinase on chromosome X (BMX), phosphoinositide. Treat B cell neoplasms in combination with inhibitors of 3-kinase (PI3K), transforming growth factor b-activated kinase-1 (TAK1), and / or Src family kinases It is that way. |