| abstract |
The present invention relates to the use of specific RNA sequences as drugs. The invention particularly relates to the use of nucleolar small RNA (snoRNA) that we have shown to be involved in the mechanism of aging. The snoRNAs of the invention typically prevent or treat degenerative diseases, laminopathy, diabetes, obesity, or cancer, in order to control the detrimental effects of aging, particularly to increase patient resistance to stress. As well as, in general, can be used to extend the life of a patient. The snoRNA of the present invention can also be used to treat fertility. The present invention further includes vectors, cells, genetically modified animals and compositions capable of expressing the snoRNAs described in the present invention, and prevention or prevention of diseases, abnormalities or diseases associated with the mechanism of aging. It relates to a method of using one of the aforementioned products of the invention as a tool for identifying molecules that are effective in therapy. |