| abstract |
The present specification generally relates to multispecific binding molecules that bind to a plurality of bacterial virulence factors, methods for making these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecule preferably comprises at least two binding domains, such as an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain can bind to staphylococcal leukotoxin, preferably LukAB, LukD, or LukE. These multispecific binding compounds have bactericidal activity against staphylococci and can therefore be used for the treatment and / or amelioration of staphylococcal infections such as methicillin-resistant Staphylococcus aureus. |