| abstract |
This application describes chemical compounds that can act as inhibitors of, or otherwise modulate, the activity of bromodomain-containing proteins, including bromodomain-containing protein 4 (BRD4), as well as such compounds And compositions containing these, and methods of using and making such compounds. Compounds include compounds of Formula I wherein R, R 2 , R 3 , R 4 , R 7 , W, X are as described herein, and Z is unsubstituted or substituted Selected from the group consisting of isoxazolyl and unsubstituted or substituted pyrazolyl. Also provided herein are methods for the preparation and use of the compounds, as well as pharmaceutical compositions containing them. |