| abstract |
PROBLEM TO BE SOLVED: To provide a method and a compound useful for detection and treatment of leukemia and malignant lymphoproliferative disorder. A method of damaging progenitor cells of hematological cancers (eg, leukemias and lymphomas) by selectively targeting cells expressing CD123 is provided. Further provided are useful compounds that selectively bind to CD123 and damage blood cancer progenitor cells. The compounds can include cytotoxic moieties such as, for example, radioisotopes, chemotherapeutic agents. [Selection figure] None |