| abstract |
Provided is an analog of compstatin which is a complement inhibiting peptide. A compound which is a modified compstatin peptide (ICVVQDWGHHRCT (cyclic C2-C12), wherein the modification is compared to an unmodified compstatin peptide under equivalent conditions: (1) C3 of the peptide, Added components or substituted N-terminal components that improve C3b or C3c binding affinity, (2) solubility of peptides in aqueous liquid and / or (3) plasma stability and / or plasma residence time of peptides The added components are D-Tyr, D-Phe, Tyr (Me), D-Trp, D-Cha, Cha, Phe, Sar, Arg, mPhe, mVal, Trp, mIle, D-Ala. , MAla, Thr or Tyr, wherein the substituted N-terminal component is the I-Ile at position 1 Ac-Trp or Dipep It is obtained by replaced with de Tyr-Gly, compound. [Selection figure] None |