| abstract |
Provided is a method for treating the disappearance of alveolar bone by administration of a specific antibody against periodontal tissue destruction and alveolar bone loss due to periodontal disease. The alveolar bone is administered to a patient in need of treatment with an amount of anti-sclerostin antibody effective to reduce the distance between the cement enamel border and the alveolar crest at a dose of 5 to 1,000 mg per week. A method for treating disappearance. The antibody is preferably administered locally to the lesion gingiva or the periodontal pocket, and prior to administration of the antibody, a standard care therapeutic agent selected from PERIOSTAT® or chemically modified tetracycline-3 is used. A method of treatment, preferably administered, and further preferably administered a second bone strengthening therapeutic selected from parathyroid hormone, teriparatide, bisphosphonate, RANKL antibody and DKK-1 antibody. [Selection figure] None |