abstract |
Disclosed are polymorphs of 4- [2-dimethylamino-1- (1-hydroxycyclohexyl) ethyl] phenyl 4-methylbenzoate hydrochloride, methods of making them, and uses thereof. An angle 2θ (± 0.2 degrees 2θ) obtained using CuK α radiation and having 5.899, 11.799, 14.481, 15.440, 18.420, 19.800, and 23.620. [4- [2-dimethylamino-1- (1-hydroxycyclohexyl) ethyl having a crystal structure of crystal form II, characterized by showing a powder X-ray diffraction pattern having a characteristic peak represented by ] A method for preparing crystals of phenyl 4-methylbenzoate hydrochloride] dihydrate, wherein 4- [2-dimethylamino-1- (1-hydroxycyclohexyl) ethyl] phenyl 4-methylbenzoate hydrochloride is Placing in 75% -92.5% humidity, 25 ° C. for 5-10 days in the absence of solvent. [Selection figure] None |