| abstract |
Disclosed is a microparticulate form of trans-clomiphene useful for the treatment of various hormone dependent disorders. The present invention provides trans-clomiphene and pharmaceutically acceptable salts and solvates thereof characterized in that trans-clomiphene is in particulate form having a defined size range. The present invention relates to pharmaceutical compositions comprising or formulated using trans-clomiphene or pharmaceutically acceptable salts and solvates having a defined size range, and secondary gonad function Those in the treatment of disorders including hypotension, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostatic hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer Also related to the use of. [Selection] Figure 1 |