| abstract |
Disclosed is a tetrahydroimidazo [1,5-d] [1,4] oxazepine compound or a pharmaceutically acceptable salt thereof having group II metabotropic glutamate receptor antagonistic activity. Formula (I): [Wherein, R is a methyl group or a fluoromethyl group, R 1 is a fluorine atom, a methoxy group, a fluoromethyloxy group or the like, R 2 is a hydrogen atom, and R 3 is a hydrogen atom. R 4 is an ethyl group, an isopropyl group, a tert-butyl group, a cyclobutyl group, a cyclopropyl group, or the like. ] Or a pharmaceutically acceptable salt thereof. [Selection figure] None |