| abstract |
A serine protease construct targeting a cell is provided. Such constructs can be used in methods for targeted cell killing, such as to treat cells of a proliferative disease (eg, cancer). In some aspects, a recombinant serine protease, such as a granzyme B polypeptide, is provided that exhibits improved stability and cytotoxicity. Methods and compositions for treating lapatinib or trastuzumab resistant cancer are also provided. [Selection figure] None |