abstract |
Cancers associated with a deficiency in the enzyme phosphatase-tension homolog (PTEN), cancers such as small cell lung cancer, meningioma, head and neck cancer, glioblastoma multiforme, anaplastic astrocytoma, and colorectal cancer Of a composition for the treatment. A composition comprising a therapeutically effective amount of a compound of formula (I), or a single isomer, stereoisomer, enantiomer or mixture thereof. (Groups Y and Z are independently substituted aryl groups or heteroaryl groups H, alkenyl, alkoxy, alkyl, etc .; R 1 to R 3 are each independently H, halogen, alkenyl, alkoxy, etc .; A and B are Each independently H, halogen, alkyl, OH, etc .; R 4 and R 5 are each independently H, alkyl, cycloalkyl, etc.) [Selection] Figure 1 |