| abstract |
A compound that selectively inhibits the activity of one or a subset of anti-apoptotic Bcl-2 proteins, such as anti-apoptotic Bcl-xL protein, and is effective for the treatment of various cancers including leukemia, and the compound A pharmaceutical composition comprising: A compound represented by formula (I) and a pharmaceutical composition containing the compound. [X is 1,3-benzothiazole: Y 1 is phenylene; L 1 is methylene, O, CO, OCH 2 , NH, NHCOCONH, S, NHSO 2 , SO 2 , 2-oxo- 1 , 2-dihydropyridyl Group: Y 2 is a tricyclo [3.3.1.1 3,7 ] dec-1-yl group; Z 1 is a carboxyl group; R 3 is a cyano group or a methyl group; p is 0 or 1; m is 0; n is 0] [Selection figure] None |