| abstract |
A mutated attenuated polypeptide ligand attached to an antibody, wherein the antibody expresses a mutant ligand, an antigen to which the antibody binds on its surface, and reception of the ligand A polypeptide construct comprising a polypeptide ligand directed to the body is provided. The present invention relates to a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen-binding portion thereof that binds to a cell surface associated antigen, wherein the ligand lacks expression of said antigen. Polypeptide constructs comprising at least one amino acid substitution or deletion that reduces its efficacy against are provided. [Selection figure] None |