| abstract |
Peptidomimetic macrocycles with improved properties are provided. The present invention provides biologically active peptidomimetic macrocycles having improved properties compared to their corresponding polypeptides. The present invention further provides methods for preparing such macrocyclic molecules and methods for use in therapeutic applications, for example. For example, the present invention provides a method for increasing the in vivo half-life of a helical polypeptide by placing one or more crosslinks. In some embodiments of the method, the in vivo half life of the polypeptide is increased by an average of at least 50-fold compared to the corresponding polypeptide without the crosslink. [Selection figure] None |