| abstract |
Novel EP4 receptor selective pyrrolidin-2-one (γ-lactam) derivatives and their use as therapy for EP4 receptor mediated diseases and conditions. A compound represented by formula (I). The compounds are EP4 agonists useful for the treatment of glaucoma, osteoporosis, fractures, alveolar bone loss, orthopedic transplants, alopecia, neuropathic pain, and related diseases. Pharmaceutical compositions and methods for treating the above-mentioned pathological conditions or diseases containing the compounds. [Selection figure] None |