http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017186338-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6afe8cb97d226ce0a219e85b25ae5d05 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-241 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate | 2017-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e96faa75eb71b24ee8aa99a9e277dc4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_328e783601ae3c2a1478c48bbf71eb76 |
| publicationDate | 2017-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2017186338-A |
| titleOfInvention | Method for modifying antibodies and modified antibodies having improved functional properties |
| abstract | Use of sequence-based analysis and rational strategies to modify and improve the structural and biophysical properties, stability, solubility and / or antigen binding affinity of immunobinders, particularly single chain antibodies (scFv) Providing a way to do it. An antibody or antigen-binding fragment thereof comprising (i) a heavy chain variable region comprising a VH framework residue or a fragment thereof and / or (ii) a light chain variable region comprising a VL framework residue or a fragment thereof. Mutating one or more amino acid positions within VH framework residues, VL framework residues or VH and VL framework residues, a) the variable region is a human VH3 heavy chain variable region, human VH1 heavy Antibody or antigen-binding fragment thereof comprising a substitution selected from the amino acids of each region of a chain variable region, human VH1b heavy chain variable region, human Vκ1 light chain variable region, human Vκ3 light chain variable region and human Vλ1 light chain variable region An antibody or antigen-binding fragment thereof that is more stable and soluble than the parent. [Selection figure] None |
| priorityDate | 2007-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.