| abstract |
An anti-Notch3 antibody, an anti-Notch3 antibody-drug conjugate, and methods for preparing and using the same. A heavy chain variable region comprising CDR1, CDR2 and CDR3 represented by an amino acid sequence comprising a specific sequence and a light chain variable region comprising CDR1, CDR2 and CDR3 represented by an amino acid sequence comprising a specific sequence An isolated antibody or antigen-binding fragment thereof that binds to Notch3. An antibody drug conjugate represented by the formula: Ab- (LD) p or a pharmaceutically acceptable salt thereof. (Ab is the antibody or antigen-binding fragment thereof; L is a linker; D is a drug; p is an integer of 1 to 12) [Selection figure] None |