abstract |
A T cell engage antibody construct having dual specificity for PSMA and CD3, a polynucleotide encoding the antibody construct, a vector containing the polynucleotide, a host cell expressing the construct, and a pharmaceutical composition containing them Offer. A first domain that binds to PSMA, a second domain that binds to an extracellular epitope of human and macaque CD3ε chains, and two polypeptide monomers each comprising a hinge, a CH2 domain, and a CH3 domain. An antibody construct comprising a third domain comprising a third domain, wherein the two polypeptide monomers are fused to each other through a peptide linker. [Selection figure] None |