| abstract |
An object of the present invention is to provide an antitumor treatment with an oncolytic virus. A method of treating a human having a solid tumor expressing NECL5 (Nectin-like protein 5) comprising the following steps: a chimeric poliovirus construct comprising a poliovirus Sabin type I strain, wherein the poliovirus comprises A construct having a human rhinovirus 2 (HRV2) internal ribosome entry site (IRES) in the 5 ′ untranslated region of the poliovirus between the poliovirus cloverleaf and the poliovirus open reading frame, Administering directly to the tumor in a human. [Selection figure] None |