| abstract |
The present invention aims to use a polypeptide comprising a complex capsid sequence that binds epitopes of many circulating virus strains to produce a more robust immunological response against multiple virus strains. . The object of the present invention is to provide at least one polypeptide having a complex amino acid sequence. The complex amino acid sequence is derived from a consensus sequence corresponding to capsid proteins of two or more circulating strains of non-enveloped virus, wherein at least one polypeptide forms a virus-like particle when expressed in a host cell, Contains at least one different amino acid as compared to each of the capsid sequences of two or more circulating strains. [Selection figure] None |