| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0eb2fd8bb5535d59d4e15b75290ccc7b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2521-101 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-35 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2017-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4cee82248effd553ec7768bfd891a16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a606e1363e9066b69214636837ab9eb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a097d4631f8d48825070f88f6ef693fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cbc3a329e9c9d8d1a349780223e4550
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed8bd973c23d5cad25aea56aafc0b4ff |
| publicationDate |
2017-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2017148052-A |
| titleOfInvention |
Mutant pore |
| abstract |
Nucleic acid sequencing using nanopore detection is provided. An MspA mutant which is a porin derived from Mycobacterium smegmatis, wherein a specific 37 amino acids of MspA are replaced with specific amino acids at each amino acid position. Msp variants improve nucleotide discrimination. In addition, the mutant increases the current range (which makes it easier to distinguish different nucleotides) and reduces state fluctuations (which increases the signal-to-noise ratio). In addition, as the nucleic acid moves through the pore, the number of nucleotides involved in the current decreases. This makes it easier to identify the direct relationship between the current observed when the nucleic acid moves through the pore and the nucleic acid sequence. [Selection figure] None |
| priorityDate |
2011-02-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |