| abstract |
A novel antibacterial peptide and use thereof are provided. A peptide having 8 to 12 consecutive amino acids represented by formula (1) and having an N-terminus and a C-terminus, or a derivative thereof. Ter1-X 1 -B 1 -X 2 -B 2 -X 3 -Z 1 -Z 2 -X 4 -Ter2 ยทยท (1) (X 1 ~X 3 is each independently an amino acid having a basic side chain Preferably arginine, lysine, 6-hydroxylysine, homoarginine, 2,4-diaminobutyric acid, arginal, etc .; Z 1 and Z 2 are cysteine or cysteine and alanine, respectively; B 1 and B 2 are each independently on the aliphatic side Amino acid having chain or basic side chain; Ter1 is N-terminal amino acid, X 1 free N-terminal amino group or amino group having basic side chain; Ter2 is C-terminal amino acid, X 4 free C-terminal carboxyl group or modification C-terminal carboxyl group) The peptides are effective for the treatment and prevention of inflammatory and infectious diseases caused by microorganisms such as bacteria or fungi. [Selection figure] None |