| abstract |
The present invention provides stimulation of the WNT pathway in reprogramming somatic cells. The present invention provides compositions and methods for use in reprogramming somatic cells. The compositions and methods of the invention can be used to form or modulate (eg, enhance) pluripotent stem cells induced, for example, by reprogramming somatic cells. Reprogrammed somatic cells are useful for a number of purposes, including treating or preventing medical conditions in an individual. The present invention further provides methods for identifying agents that reprogram somatic cells to a pluripotent state and / or enhance the speed and / or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway. [Selection] Figure 1 |