| abstract |
Disclosed is a method for pain research, imaging and treatment, and a composition for pain research, imaging and treatment. Saxitoxin analog compounds, compositions, pharmaceutical compositions, methods of synthesizing saxitoxin analogs, imaging methods, and methods of treatment including pain are provided. Saxitoxin (STX), goniotoxin (GTX), and zetekitoxin, and mutant STX compounds bind to sodium channels and are effective to reduce or block the flow of sodium ions through such channels. Such channel blocking affects nerve and muscle action and can be effective to reduce or block pain sensation, relax muscles, reduce muscle spasms, and reduce wrinkles. [Selection] Figure 5 |