| abstract |
PROBLEM TO BE SOLVED: To provide a pre-B cell colony promoting factor or Rho-related coiled coil-forming protein activity inhibitor as a therapeutic agent for cancer, autoimmune disease, inflammatory disorder and metabolic disorder. A compound such as N- {4-[(3-phenylpropyl) carbamoyl] phenyl} -1,3-dihydro-2H-isoindole-2-carboxamide, exemplified by formula (Ic). (Where X1 to X3 are substituted / unsubstituted C or N; R2 is substituted / unsubstituted alkyl, phenyl, heterocyclic, cycloalkyl, etc.) None |