abstract |
An apolipoprotein formulation with a fixed dosage effective in prophylactic and / or therapeutic treatment of diseases or conditions including cardiovascular disease, acute coronary syndrome, atherosclerosis, unstable angina, and myocardial infarction Offer. Fixed dosage apolipoprotein formulations exhibit relatively reduced patient-to-patient variability compared to body weight adjusted dosages. Typically, the apolipoprotein formulation comprises ApoA1, one or more lipids (eg phosphatidylcholine, sphingomyelin and / or phosphatidylglycerol) and optionally a surfactant (eg a level of cholate that does not induce hepatotoxicity). Is a reconstituted high density lipoprotein formulation. [Selection figure] None |