| abstract |
A human antibody and a specific binding sequence thereof for use in stroke and ischemia or ischemic conditions. Specific binding members, in particular human antibodies, in particular recombinant antibodies, and fragments thereof are provided which are capable of binding to neurons in the CNS, recognizing them and inducing responses in neurons of the CNS. The These antibodies are useful for diagnosis and treatment of conditions associated with nerve damage, nerve injury, or neurodegeneration and neurodegenerative diseases, and are particularly useful for the treatment or amelioration of stroke or cerebral ischemia. Antibodies of the invention, their variable regions, or CDR domain sequences, and fragments thereof are also combined in therapy with chemotherapeutic agents, immunomodulators, or neuroactive agents, and / or other antibodies or fragments thereof. Can also be used. |