| abstract |
The present invention provides modified polynucleotides for the production of biologics and proteins associated with human diseases. A first nucleoside of a linked nucleoside, wherein the first region encodes a polypeptide of interest, wherein the polypeptide of interest is selected from a number of reference polypeptide sequences. And the first flanking region of any of the natural 5′UTRs of nucleic acids encoding any of the reference polypeptide sequences and functional variants thereof A sequence of linked nucleosides selected from: a first flanking region; a second flanking region located at the 3 ′ end of said first region; and a 3 ′ tail sequence of a linked nucleoside, An isolated polynucleotide comprising two adjacent regions. [Selection figure] None |