http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017119704-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_927cef905d17253d40a2e1a4dbfc8296 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_764c37797762f79bedf08832dbf3a65a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C327-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-621 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C219-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-609 |
| filingDate | 2017-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2bbea8535f5f72aef6b493a3328b16b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fac05669316effe24d3e388dfb9f027a |
| publicationDate | 2017-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2017119704-A |
| titleOfInvention | Positively charged water-soluble prodrug of aspirin |
| abstract | The object of the present invention is to increase the solubility of acetylsalicylic acid in gastric juice and to allow aspirin to be transdermally administered (topical application), the permeability of aspirin through membranes and skin barriers. Is to avoid the side effects of aspirin. A novel positively charged prodrug represented by the formula (1) of acetylsalicylic acid and analogs thereof was synthesized. The positively charged amino groups of these prodrugs not only greatly increase the solubility of the drug, but also bind to the negative charge on the membrane phosphate head group, pushing the prodrug into the cytosol. The prodrug, diethylaminoethyl acetylsalicylate acetate, diffuses through human skin ˜400 times faster than acetylsalicylic acid itself and ˜100 times faster than ethyl acetylsalicylate. [Selection] Figure 2 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111508613-A |
| priorityDate | 2017-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.